narcotic effects in the brain involve activity related to receptors. group of answer choices a. acetylcholine b. gaba c. opioid d. norepinephrine and dopamin

Answers

Answer 1

Narcotic effects in the brain involve activity related to the receptors: (c) opioid.

Narcotic effect is the effect of the drugs upon the brain that causes good as well as bad effects. If used in required and prescribed doses, drugs can reduce pain and provide the state of sleep. However when the dose of drugs increases, it results in addiction.

Opioid is the class of drugs used as a pain reliever. These drugs bind to the opioid receptors of the brain. They are quite powerful drugs and hence overdose can result in deleterious effects over the body. The different drugs under opioids are heroin, morphine, codeine, etc.

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Related Questions

What unique characteristic does the bonding of carbon to other atoms have and why is this important for organic molecules?

Answers

Explanation:

The carbon atom has unique properties that allow it to form covalent bonds to as many as four different atoms, making this versatile element ideal to serve as the basic structural component, or “backbone,” of the macromolecules. Individual carbon atoms have an incomplete outermost electron shell.

The ability of forming long durable chain is an unique characteristic of Carbon that is important  for organic molecules.

The Carbon can form four bond with different atom anf form a long chain of different size. These can also be branched. The long chains are very durable.

Silicon and some other elements can do so but the chains are relatively short and non-durable.

Therefore, the ability of forming long durable chain is an unique characteristic of Carbon that is important  for organic molecules.

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Describe the process of expiration

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Expiration is the process of exhalation where the air is removed out from the lungs.

Expiration is the removal of waste air out from the body through the lungs. The diaphragm muscles present beneath the lungs relax, and the volume of the thoracic cavity decreases. Also the pressure increases along with the decrease of volume. All these activities make the lungs contract and the air is moved out.

Lungs are the respiratory organs that are involved in the exchange of gases. There is a pair of lungs in each human. The whole lungs are covered by thin sac like structure called alveoli that increase the surface area of the lungs in order to achieve the maximum exchange of gases.

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what would happen if an enzyme inhibitor for the enzyme phosphodiesterase (pde) was applied to a vertebrate eye?

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If an enzyme inhibitor for the enzyme phosphodiesterase (PDE) is applied to a vertebrate eye, it would likely have an impact on the visual signaling pathway and potentially affect vision.

Phosphodiesterase is an enzyme that plays a crucial role in the regulation of cyclic nucleotide levels in cells, particularly cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP). In the context of the vertebrate eye, PDE is involved in the phototransduction process, which converts light signals into electrical signals that can be interpreted by the brain.

In the absence of an inhibitor, PDE functions to break down cGMP, leading to a decrease in its concentration. This decrease in cGMP levels is necessary for the closing of ion channels in the outer segment of photoreceptor cells, which helps maintain the cell's resting potential and prevents continuous signal transmission. This process allows the photoreceptor cells to respond to changes in light intensity.

When an inhibitor for PDE is applied to the vertebrate eye, it would prevent the breakdown of cGMP, resulting in elevated levels of cGMP within the photoreceptor cells. This prolonged presence of cGMP would keep the ion channels open, preventing the hyperpolarization of the photoreceptor cell membrane and altering the signaling process.

The consequence of inhibiting PDE in the vertebrate eye would likely lead to an increase in the sensitivity of photoreceptor cells to light stimuli. This increased sensitivity may cause visual disturbances, such as enhanced brightness perception, difficulty adapting to changes in light intensity, or decreased visual acuity. Additionally, prolonged exposure to high levels of cGMP could potentially lead to desensitization or adaptation of the phototransduction pathway, impairing the normal response to light stimuli.

It's important to note that the specific effects of an enzyme inhibitor for PDE in the vertebrate eye would depend on various factors, including the concentration of the inhibitor, the duration of exposure, and the individual's overall eye health. Any application of such inhibitors should be done under proper medical supervision to assess and mitigate potential risks or side effects.

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What is the main reason that we can use antibiotics that interfere with protein synthesis in bacteria without being affected ourselves? а Antibiotics bind to the ribosomal sites in the bacteria, which are different than those found in eukaryotes, to interfere with protein synthesis. b Antibiotics bind to the mitochondrial sites in the bacteria to interfere with protein synthesis. Antibiotics affect both prokaryotic and eukaryotic cells, but prokaryotes are more sensitive to them. d Antibiotics cannot bind to the eukaryotic ribosomes because they are larger.

Answers

The main reason that we can use antibiotics that interfere with protein synthesis in bacteria without being affected ourselves is because of the difference in ribosomal sites between bacteria and eukaryotes. The correct answer is option а. Antibiotics bind to the ribosomal sites in the bacteria, which are different than those found in eukaryotes, to interfere with protein synthesis.

This difference in ribosomal sites allows the antibiotics to specifically target the bacteria without affecting our own cells. The other options are incorrect because antibiotics do not bind to mitochondrial sites (option b), they do not affect both prokaryotic and eukaryotic cells equally (option c), and the size of eukaryotic ribosomes is not the reason why antibiotics cannot bind to them (option d).

In conclusion, the main reason that we can use antibiotics that interfere with protein synthesis in bacteria without being affected ourselves is because of the difference in ribosomal sites between bacteria and eukaryotes. This allows the antibiotics to specifically target the bacteria without affecting our own cells.

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correct answer gets brainiest. and i’m telling u. if u guess or leave a link, ur getting reported and that’s not a threat

correct answer gets brainiest. and im telling u. if u guess or leave a link, ur getting reported and

Answers

Answer:

I'm pretty sure its skin

in general, lymphocytes a) spend most of their time in lymphatic tissue. b) have relatively short life spans. c) have two nuclei. d) are produced and mature only in red bone marrow. e) are located primarily in the blood stream.

Answers

Lymphocytes , in general: A) spend most of their time in lymphatic tissue. Hence option A) is the correct answer.

What are lymphocytes?

Lymphocyte is a type of white blood cell in the immune system of vertebrates. Lymphocytes have natural killer cells, T cells and B cells. They are found in lymph, which prompted the name lymphocyte.

Lymphocytes make up up to 18% to 42% of circulating white blood cells.

If you have low numbers of lymphocytes , there is a higher risk of infection. Lymphopenia symptoms ranges from mild to serious and are correlated to the severity of the lymphopenia  but some people show no symptoms.

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The heart is an organ because it
a. maintains homeostasis.
b. is made up of different kinds of tissues.
c. contains blood.
d. contains muscle.

Answers

Answer:

d

Explanation:

Your heart is an organ that’s largely made up of muscle. It has the vital function of working to pump blood to the organs and tissues of your body.

Answer:

b or d

Explanation:

Its b  or c I am not too sure. I think its d though.

What are some ways that scientists and engineers are using our understanding of DNA?

Answers

You can just be gay and yeah

the period of time from about 20 years old to the end of the reproductive years is called

Answers

The period of time from about 20 years old to the end of the reproductive years is called the reproductive age or reproductive phase.

This period typically lasts from the onset of menstruation until menopause, which usually occurs between the ages of 45 and 55. During this phase, individuals are capable of reproducing and may choose to start a family or have children. It is also a time when individuals may experience hormonal changes and fluctuations, as well as potential health issues related to reproductive organs and functions. Proper healthcare, including regular check-ups and screenings, is important during this phase to maintain reproductive health and overall well-being.
The period of time from about 20 years old to the end of the reproductive years is called the reproductive age or fertility period. This phase typically ranges from the onset of puberty, when an individual becomes sexually mature, until the end of their reproductive capabilities. For women, this period usually starts in their late teens or early 20s and lasts until they reach menopause, which commonly occurs between the ages of 45 and 55. For men, the reproductive age can extend from their early teens to their late 40s or early 50s, although sperm quality tends to decline as they age.

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1. What is the significance of the reason rule and sequencing?

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Explanation:

A biological sequence may be defined as a single but a continuous molecule of a protein or a nucleic acid.  It can be a genetic map or an actual sequence of the amino acids or the nucleic acids. It can also be some more complicated data structure building of a composite view from other entries.

Sequencing is mostly used in molecular biology for studying the  genomes and proteins that they  encode.

The reason rule is the law of antitrust that says that a trade practice which violates the Act of Sherman only if that practice is the unreasonable restraint of some trade which is based on some factors.

The organelle involved in breaking down other organelles that have outlived their usefulness is the.

Answers

The organelle involved in breaking down other organelles that have outlived their usefulness is the lysosome. Lysosomes are spherical organelles found in animal cells that contain a variety of hydrolytic enzymes. These enzymes are capable of breaking down a wide range of biological molecules, including proteins, carbohydrates, lipids, and nucleic acids.

Lysosomes are formed by the Golgi apparatus, which packages hydrolytic enzymes into vesicles and transports them to the lysosomes. When a lysosome fuses with another organelle, such as an old or damaged mitochondrion or peroxisome, the hydrolytic enzymes in the lysosome are released and begin to break down the organelle's molecules into smaller building blocks that can be recycled by the cell.

In this way, lysosomes play a critical role in the process of cellular degradation and recycling, helping to maintain the health and function of the cell by removing damaged or unnecessary organelles.

An astronaut is planning a trip to a newly-discovered planet according to the law of universal gravitation, the astronaut weight in the new planet will be greater than his weight on earth if:

Answers

The new planet has more mass than Earth but the same radius. The mass of the astronaut will be calculated by the use of Newton's gravitational equation. The weight of the astronaut depends completely on its mass and the gravitational acceleration of the planet.

Gravitational acceleration is directly proportional to the mass of the planet and indirectly proportional to the radius of the planet. Hence, when the gravitational acceleration increases the planet's mass will increase therefore the radius will decrease. The astronaut's mass will depend on these factors.

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the triple helix structure of collagen protein is possible largely due to:_____.

Answers

glycine and its small side chain

How much radiation is emitted from earth surface at 300 K

Answers

The radiation emitted by the Earth's surface at 300K is 459.27 Wm -2(in power -2)

The cell walls are connected by strings of cytoplasm called ____.

Answers

i don’t know if i’m correct or not but i think it’s a glycan cross-linkage

ok ima make this simple so yall can earn some easy points name two viruses​

Answers

Answer: Ebola and corona

when the blood pressure or ocular tension is dictated with millimeters of mercury the expression should be transcribed as:

Answers

When blood pressure or ocular tension is measured in millimeters of mercury, the expression should be transcribed as "mmHg."

Millimeters of mercury is a unit of pressure measurement that is used to measure the pressure in blood vessels in order to assess blood pressure, and it is also used to measure the pressure within the eye in order to assess ocular tension. The abbreviation "mmHg" is used to represent millimeters of mercury. Therefore, when blood pressure or ocular tension is measured in millimeters of mercury, the expression should be transcribed as "mmHg."

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When blood pressure or ocular tension is measured in millimeters of mercury, the abbreviation mm Hg is used. Hence, the expression that should be transcribed when blood pressure or ocular tension is measured with millimeters of mercury is "mm Hg.

Millimeters of mercury (mm Hg) is a unit of pressure measurement. It's commonly used to measure blood pressure and ocular pressure. The pressure exerted by a column of mercury 1 millimeter high is equal to 1 mm Hg. The normal blood pressure range for adults is 90 to 119 mm Hg systolic and 60 to 79 mm Hg diastolic, according to the American Heart Association (AHA).

If blood pressure or ocular tension is measured using units other than mm Hg, the appropriate units must be used. For example, if blood pressure is measured in pounds per square inch (psi), the appropriate abbreviation would be "psi."

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Suppose you find an animal that had gills and a backbone. What can you infer about where the animal lives and the type of animal it might be?

Answers

Vertebrates are animals that have a backbone or spinal column, also called vertebrae. These animals include fish, birds, mammals, amphibians, and reptiles. How are they classified? Invertebrates are any other animal that is classified out of that class.

Explanation:

Vertebrates are animals that have a backbone or spinal column, also called vertebrae.

What are vertebrates?

Organisms with an internal backbone, sometimes known as a vertebra, are referred to as vertebrates. They have a robust bone skeleton that anchors muscle and supports the body's tissue. Invertebrates are defined as animals without spines.

A vertebral column is present in all animals. The nerve cord is encased and shielded by the vertebral column, or backbone.

Vertebrates also have a fully formed brain, eyes, a heart-powered circulatory system, a pharynx, and a muscular mouth. Vertebrates include animals including humans, birds, mammals, reptiles, amphibians, and fish. Vertebrates are categorized into seven living groups.

Therefore, Vertebrates are animals that have a backbone or spinal column, also called vertebrae.

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The process by which a cell takes in a large particle is called

Answers

Answer:

Phagocytosis, also known as cell eating.

to support the symbiotic hypothesis presented in the passage, mitochondria should be similar to bacteria in which of the following ways?

Answers

To support the symbiotic hypothesis presented in the passage, mitochondria should be similar to bacteria in possessing their own DNA

Option (A) is correct.

The symbiotic hypothesis proposes that mitochondria originated from a symbiotic relationship between an ancestral eukaryotic cell and a free-living bacterium. To support this hypothesis, mitochondria should exhibit similarities to bacteria.

One of the key similarities is the possession of their own DNA. Bacteria have their own distinct genetic material in the form of DNA, and mitochondria also possess their own DNA, known as mitochondrial DNA (mtDNA).

This similarity in DNA structure and function suggests a shared evolutionary origin between mitochondria and bacteria. Therefore, option A, "Possessing their own DNA," is the correct choice to support the symbiotic hypothesis.

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The complete question:

To support the symbiotic hypothesis presented in the passage, mitochondria should be similar to bacteria in which of the following ways?

A) Possessing their own DNA

B) Reproducing by binary fission

C) Having a cell wall

D) Engaging in photosynthesis

For all of the following questions, a grumpy prince is crossed with a homozygous happy, heterozygous dwarf.



A= happy a= grumpy, B= dwarf b= prince



What is the genotype of the dwarf?

Answers

The tall plant's genotype is Tt because there are exactly one tall plant for every one dwarf plant in the offspring.

What else is meant by homozygous?

In terms of genetics, being homozygous means that you have inherited the identical alleles of a particular genomic marker from both of your biological parents. As a result, a person who possesses two identical copies of a genetic marker is said to be homozygous.

Dominant or recessive is homozygous?

When an organism is homozygous, it signifies that it possesses two copies of the same gene allele. If an organism possesses 2 copies of the identical dominant allele, it is said to be homozygous dominant, and if it possesses two copies of the same recessive gene, it is said to be homozygous recessive.

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Which of the following shows the evolutionary relationships between organisms?

Branching tree
Binomial nomenclature
Three-domain classification
Taxonomic key

Answers

Answer:

Answer is A.

Explanation:

I hope it's helpful!

Answer: A

Explanation: 100% :)

As the human population increases, scientists and enigneers look for new ways to increase the amount of food from crops. Two students perform an experiment to find out if different fertilizers increase the growth of pea plants over time. They slect four differentfertilizers for testing. They plant seeds in separate pots. Each pot receives 350mL of a fertilizer and water solution every other day. The control plants receives 350mL of tap water instead of a fertilizer solution every other day. Every 10 days, the height of each plant is measured in centimeters. Their results are shown in the data table.What does the data in the table show?A. The control plant grew the best.B. The plants with fertilizer grew better than the control plant.C. Fertilizer B is the most effective fertilizer.D. The fertilizers made the most difference in growth between day 10 and day 20.

As the human population increases, scientists and enigneers look for new ways to increase the amount

Answers

The table shows that all of the plants that received fertilizers grew more than the control plant, as the control plant has 35 centimeters in day 50 and all of the others has 43 centimeters or more. Therefore, A is incorrect.

The plant that received fertilizer B has 43 centimeters in day 50, being the shortes plant among the fertilized ones (the other has from 45 to 55 centimeters). Therefore, C is incorrect too.

On day 20, there is no big differencies between the height of the fertilized plants and the control plant. Most of them stayed in heights like 10, 11 or 12. The heights in day 50 show bigger differencies. Therefore, D is incorrect as well.

All of the plants that received fertilizers grew at least

A model of the cell cycle is shown here. A student wants to refine the model to include more details about the M phase. Modify the model by selecting the parts of the cell cycle that would be included in the M space.

A) anaphase
B) apoptosis
C) interphase
D) metaphase
E) prophase

A model of the cell cycle is shown here. A student wants to refine the model to include more details

Answers

Answer:

A) anaphase

D) metaphase

E) prophase

Explanation:

M phase where nuclear division occurs by mitosis.

The parent cell divides into two daughter cells.

Also telophase and cytokinesis occurs during M phase.

Which of the following is an example of a non contact force

Answers

Answer:

Gravity, Electrostatic force, Magnetic force

Explanation:

A non-contact force is a force that is applied to an object by another object without contact. Gravity, electrostatic force, and magnetic force all don't need two objects to be touching in order for them to work.

On the other hand, an example of a contact force is friction, because it can only occur if two objects are touching. If you want to tell the difference between a contact and non-contact force, just ask yourself if it can occur if the two objects are not touching. If it can occur while two objects aren't touching, it is non-contact, and if it can't, it is contact.

All the options given describe a force that involves contact except for the force exerted by magnets. Thus, the correct option is C.

Magnetic force is the force exerted by magnets. It can be described as the effect exerted on a charged particle due to the magnetic field of the other particle.

It is a consequence of the electromagnetic force, which is caused due to the movement of electrically charged particles.

Two objects that are oppositely charged will have a magnetic force of attraction, whereas two objects that have the same charge will have a magnetic force of repulsion.

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Your question is incomplete. The full question probably might be:

Which of the following is an example of a non-contact force?

(a) The force exerted by us to lift a bucket

(b) push a stationary car

(c) The force exerted by magnets

(d) Force due to friction​

staphyloccocus aureus is an important cause of food poisoning. several gene-encoding exotoxins are associated with s. aureus food poisoning, including sea, an exotoxin encoded by a viral gene. what sort of life cycle must this phage have?

Answers

Lysogenic is the life cycle of the phase.

The lysogenic cycle is a stage of viral reproduction during which the DNA of the virus is replicated utilizing the DNA of the host cell. Lysogenic infection occurs when a virus does not produce any proteins but instead copies its DNA or genetic material with the assistance of the host. At that time, the virus' multiplication and continued life are entirely dependent on the machinery of the host cell.

Prokaryotic cells, which primarily comprise bacteria, exhibit the lysogenic cycle most frequently. However, it can happen in eukaryotic cells, which include both animal and plant cells. The lysogenic cell frequently occurs in bacteriophages, which are viruses that infect bacteria.

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if a substance in the plasma is filtered but not produced, metabolized, reabsorbed, nor secreted by the kidney, which of these must be true?

Answers

If a substance in the plasma is filtered but not produced, metabolized, reabsorbed, or secreted by the kidney, then it means that it will be completely excreted in the urine.

The kidneys are organs that filter waste and toxins from the bloodstream. The kidneys work by filtering out substances in the blood that are harmful to the body or have served their function. The kidneys, for example, filter out excess water, urea, and minerals from the blood.

Substances that are present in the plasma but are not produced, metabolized, reabsorbed, or secreted by the kidney are excreted in the urine after filtration. This implies that the substance is not reabsorbed by the kidney since that is the only process that can lead to the substance's return to the bloodstream from the glomerular filtrate.

Only substances that are not filtered by the glomerulus or are filtered and then secreted or reabsorbed by the tubules are excluded from the urine.

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Are the phalanges distal or proximal to the metacarpals?

Answers

The hand contains five metacarpal bones that articulate proximally with the carpals and distally with the proximal phalanges

3. Algae makes energy-rich carbon compounds through
photosynthesis.
4. A volcano erupts.
5. Carbon dioxide dissolves in rainwater.
<
6. Humans use gasoline to power their cars.
7. Organisms carry out cellular respiration to release
energy from food molecules.
Check Answer

Answers

A complementary process in nature either adds (options 3, 6, and 7) or removes ( options 4 and 5) carbon dioxide from the atmosphere.

Complementary processes and it's benefits

The processes that leads to the addition of carbondioxide back to the atmosphere include the following:

The eruption of volcanoes.

Cellular respiration carried out by organisms to release energy from food molecules.

The use of gasoline to power cars

The processes that leads to the removal of carbondioxide from the atmosphere include:

The production of energy-rich carbon compounds through photosynthesis.

The dissolution of carbondioxide in rainwater.

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Select the correct answer.
Which statement is true about the relationship between carrying capacity and population size?
OA. If a population is more than the carrying capacity, it leads to a positive growth rate and increased population.
OB.
If a population is less than the carrying capacity, it leads to a negative growth rate.
O C.
If a population is less than the carrying capacity, it leads to a positive growth rate and increased population.
If a population is more than the carrying capacity, it leads to a neutral growth rate.
O D.
Reset
Next

Answers

The correct answer to the question is option B: If a population is less than the carrying capacity, it leads to a negative growth rate.

The carrying capacity refers to the maximum number of individuals that an ecosystem or environment can support without causing any harm to its sustainability. It is determined by factors such as the availability of resources, space, and the capacity to absorb wastes. When a population size exceeds the carrying capacity, it leads to a depletion of resources, competition for survival, and environmental degradation. As a result, the population growth rate reduces and may even become negative if the resources are severely limited. On the other hand, if the population size is below the carrying capacity, the environment can support more individuals, and resources are abundant. In this scenario, the population growth rate is positive, and the population size can increase. However, this growth rate may slow down as the population approaches the carrying capacity, and resources become scarcer. It is essential to understand the relationship between carrying capacity and population size to ensure the sustainability of the ecosystem and its inhabitants. Human activities that exceed the carrying capacity of the environment can have long-term consequences, such as resource depletion, loss of biodiversity, and climate change. Therefore, it is crucial to adopt sustainable practices that respect the carrying capacity of the environment and maintain its balance.

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Write a program that creates an array of four float elements. Use a for loop to read and store a float value at each index in the array. Then use a for-each loop to print out each element to the console. Which expression is equivalent to 7.5(22 + 1.2s)? Carbonic acid weathering limestone aChemical Change bPhysical Change Directions: Use the distributive property to multiply the following binomials. Write your answer in standard form! a.) (x+5)(x-2) y^2 - 19 = 0 find the sum and product What are the slope and the y-intercept of the linear function that is represented by the graph?54321-5 4 3 2 13 4 52The slope is , and the y-intercept is -2.2The slope is 3, and the y-intercept is 3.and Exit PLEASE HELP!!Which of the drawings do you find most interesting? Why? Artists in Context Choose at least two artists from the Renaissance period. Research their lives and their work using a variety of online and print resources. You will present your research by Writing a research paper (2-3 pages minimum) whichever medium you choose to present your research, you will need to make sure that you answer slash address the following questions: how did each artist's work reflect the ideas or historical events of the renaissance? how was their work similar or different? did they influence future artists, and if so, how? HELP NEED ASAP!!!!!! 4.3.9 english 9 practice it identifies how people relate to nature and their physical environment QUESTION Which of the following statements is true? Human bone is rigid, hard, and dead tissue. During the resorption phase, protein is released into the blood. Bone remodeling responds to the functio a client with acquired immune deficiency syndrome (aids) informs the nurse of difficulty eating and swallowing, and shows the nurse white patches in the mouth. what problem related to aids does the nurse understand the client has developed? Which of the following is not a factor that contributed to the collapse of the Soviet Uniona.high income intake versus debtc.state farmsb.slow increase of GNPd.collective farms How do i do ghe work for -3/4=x/24 Sam made fruit punch for a party. He mixed 3 gallons of orange juice, 2 quarts of pineapple juice, 4 pints of cranberry juice, and 6 cups of apple juice. How many quarts did he make in all? ________ are information system (IS) professionals who understand both business and information technology. Network administrators Development analysts Database designers Systems analysts Kelly's monthly profit for selling candles is represented by the function P (x) = 7.5x - 200, where x represents the number of candles sold. Complete each table Maggie is participating in her school reading challenge she reads 18 of the total 25 books what person of books did she read? A company is trying to decide whether to assemble a new product in their domestic plant or to outsource it to an offshore plant. The motivation is that the labor rate in the domestic plant is $45 per hour while the offshore plant will have a labor rate of $20 per hour. The domestic plant follows a learning rate of 70% while the learning rate in the offshore plant is expected to be 85%. The first unit will take 100 hours of labor time in both plants.On an Excel spreadsheet, calculate the following:1. For Unit Numbers 1, 10 and 18, find the factor (use the Table posted in class), unit time and unit cost. You will notice that the cost differential is reducing as you produce more and more.2. Do the same calculation for Unit Number 20. This is the unit number where the domestic cost is lower than offshore. This exercise tells you that, while an offshore plant may seem very attractive due to significantly lower labor rate, Learning Rate should be taken as a strategic factor to make decisions.NOTE: You must show all the three numbers (factor, time and cost) for each unit mentioned above, for each plant. Reflect aaBC if A(-1, 4), B(1, 2), C(-2, 1) over the y-axis, then rotate the image 90 counterclockwise about the origin. What are the coordinates of the final image after both transformations?