tumour-derived csf2/granulocyte macrophage colony stimulating factor controls myeloid cell accumulation and progression of gliomas

Answers

Answer 1

Myeloid cells are attracted to and polarized to pro-invasive, immunosuppressive phenotypes by substances released by malignant tumors.

In the glioblastoma (GBM) tumor microenvironment, brain-resident microglia and peripheral macrophages build up and cause immunosuppression, which promotes tumor growth. It is debatable which CSFs are responsible for the increase of myeloid cells in gliomas, however macrophage colony stimulating factors (CSFs) regulate their recruitment during the course of peripheral malignancy.

Five human glioma cell lines and TCGA datasets were used to analyze the expression of CSF2 (encoding granulocyte-macrophage colony stimulating factor). In vitro and in vivo experiments were performed to examine the effects of stable CSF2 knockdown in glioma cells and antibodies that neutralize CSF2 or its receptor, CSF2R.

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Related Questions

12. Why is our sense of hearing important?

Answers

Answer:

As one of our most vital senses, the capacity to hear allows us to connect to the world for numerous very critical reasons. Most notably, hearing joins us to people enabling us to communicate in a manner that none of our different senses can accomplish.

Explanation:

Hearing allows us to connect with the world around us, it's beneficial to communicate with others, be able to listen for dangers, etc. Our ears can detect all sorts of noises, and all of these sounds have some sort of importance to us. Some noises can indicate danger, which is vital for survival. Hearing is also crucial for socialization; on average, a person will hear up to 70,000 words a day!

I hope this helped!! :)

Answer:

Hearing is essential for maintaining relationships and connections with friends and family, fully participating in team and community activities, and experiencing life events. Hearing makes it possible to engage, listen, laugh, and enjoy many of the things that help shape your quality of life

An organism has 18 chromosomes in its body cells. Its sex cells have 9 chromosomes.
Which statement correctly explains this?

Answers

For an organism that has 18 chromosomes in its body cells and its sex cells have 9 chromosomes, the correct statement is C, Its sex cells are haploid and a result of meiosis.

What are haploids?

Haploid cells have half the number of chromosomes as diploid cells. Mitosis is a type of cell division that produces two identical daughter cells. Meiosis is a type of cell division that produces four daughter cells, each with half the number of chromosomes as the parent cell.

In the organism described, the body cells are diploid (18 chromosomes) and the sex cells are haploid (9 chromosomes). This is because the sex cells are produced by meiosis, which is a type of cell division that reduces the number of chromosomes by half. This allows the sex cells to combine with each other to form a new diploid cell, which is the beginning of a new organism.

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Complete question:

An organism has 18 chromosomes in its body cells. Its sex cells have 9 chromosomes.

Which statement correctly explains this?

Its body cells are haploid and a result of mitosis.

Its sex cells are diploid and a result of mitosis.

Its sex cells are haploid and a result of meiosis.

Its body cells are diploid and a result of meiosis.

pleasehelp

There are multiple mid-ocean ridges located around the world. These ridges separate plates on Earth.
What natural, geologic process occurs to create mid-ocean ridges?
A) seafloor spreading
B) converging plates
C) uplift
D) folding

Answers

T he natural, geologic process that occurs to create mid-ocean ridges is A) seafloor spreading. As new oceanic crust is formed at the mid-ocean ridges, the plates on either side of the ridge move away from each other. This is due to the magma rising from the mantle and solidifying at the ridge. As the magma solidifies, it creates new oceanic crust, which moves away from the ridge, allowing the plates to move apart. This process is known as seafloor spreading, and it is responsible for the creation and widening of the Atlantic Ocean, among other features of plate tectonics

Did Atom is the smallest level of organization

Answers

Answer: yes atom is the smallest level of organization

Explanation:

Which development would most reflect Karl Marx's belief in the economic
system that he predicted would replace free markets?
A. Governments eliminate all taxes on wealthy corporations.
B. Workers share all the profits generated from a factory.
C. Companies begin to sell their products in overseas markets.
D. Businesses refuse to hire workers who demand high wages.


Which development would most reflect Karl Marx's belief in the economicsystem that he predicted would

Answers

Answer:

D. Businesses refuse to hire workers who demand high wages

Explanation:

Karl Marx's predicted that if businesses refuse to hire workers with high wages according to their value, this can lead to revolution and can destroy or replace the free markets.

10 or even 5 hardest questions about balance of nature ( in biology) I will give 20 points for an answers. HURRY Up PLEASE​

Answers

Here are 10 of the hardest questions about the balance of nature in biology:

What happens to a food chain if a key predator is removed?What is the difference between a food chain and a food web?How does climate change impact the balance of nature?What are keystone species and how do they affect ecosystems?How does human activity, such as deforestation, disrupt the balance of nature?How do invasive species disrupt ecosystems and the balance of nature?How do natural disasters, such as wildfires, affect ecosystems and the balance of nature?What role do decomposers play in the balance of nature?How does biodiversity affect the balance of nature?Can the balance of nature be restored once it has been disrupted?

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A scientist sets up an experiment to test which fertilizer has the best effect on increasing fruit size in a single variety of avocado trees. They grow one group of avocado trees using Fertilizer-A, one group using Fertilizer-B, one group using Fertilizer-C, and one group grown without any fertilizer. All the avocado trees are given the same amount of water and sunlight, and they are all grown during the same period of time. Which of the following is the independent variable in this experiment?​

the type of fertilizer used
the size of the avocados
the amount of water,sunlight, and time
the amount of water only

Answers

Independent variables affect the dependent one. The researcher changes it to analyze how the dependent variable behaves when the independent one changes. The independent variable is the type of fertilizer (A, B, and C)

What is the independent variable?

Usually, when performing experiments, researchers must define the variables affecting the experiment. These are,

Dependent variablesIndependent variablesConstant variables

Independent variables are the ones that influence or cause an effect on another variable.

The researcher is interested in knowing how the independent variable affects the dependent one, so changes the first one to observe how different values or states provoke a change in the other variable.

In the exposed example, the scientist wants to know which fertilizer has the best effect on fruit size.

Independent variable ⇒ fertilizers ⇒ Fertilizer-A, Fertilizer-B, Fertilizer-C. Fertilizers influence or affect the fruit size.

Dependent variable ⇒ Fruit size ⇒ It changes according to the fertilizer.

Constant variables ⇒ amount of water and sunlight, and growth period of time.

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Which of the following is not a property of persistent organic pollutants (POPs)?
a.
They have carbon-based molecular structures.
b.
They do not break down easily in the environment.
c.
They are insoluble in fat.
d.
They are polluting and toxic.

Answers

Answer: C

Explanation:

got a 90 on the quiz but correct if wrong

Saturated fat is the type of fat that may increase blood cholesterol levels.
If a diet history consisting of a 7-day food record shows that your saturated fat intake is above recommendations, should you worry? Why or why not? Are there any other ways or tests that can be done to find out what your risk of developing heart disease is? What other components of nutritional assessment (ABCDs) would help you determine your overall risk for heart disease?
Please state what these tests would measure and how they would help assess your risk of developing heart disease.

Answers

Answer:

Saturated fat is the type of fat that may increase blood cholesterol levels.

Explanation:

Eating too much saturated fat can raise the level of LDL cholesterol in your blood.

Dopamine receptors are
A. G-protein coupled receptors that only activate adenylyl cyclase
B. G-protein coupled receptors that can either activate or inhibit adenylyl cyclase
C. Ionotropic receptors that are excitatory
D. G-protein coupled receptors that only inhibit adenylyl cyclase

Answers

Dopamine receptors basically G-protein couples receptors which are able to activate or even inhibit adenylyl cyclase.

The correct option is option B.

G-protein-coupled receptors or GPCRs are basically the largest as well as the most diverse group of membrane receptors which are found in eukaryotes. GPCRs happen to interact with the G proteins that are present in the plasma membrane. Whenever an external signaling molecule happens to bind to a GPCR, it leads to a conformational change in GPCR which consequently triggers the interaction between the GPCR and a G protein present nearby.

The common target of these activated G proteins is adenylyl cyclase which is basically a membrane-associated enzyme which when activated catalyzes synthesis of cAMP. Dopamine receptors are also G-protein couples receptors which are able to activate or even inhibit adenylyl cyclase.

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The cell membrane performs several important functions in addition to separating the cytoplasm from the outside environment. It controls which molecules enter and leave the cell. The cell membrane is “selectively permeable,” which means it allows certain substances through and not others. One way that substances enter and leave the cell is through diffusion, the movement of particles from higher concentration to lower concentration. For example, if the concentration of salt molecules is higher inside the cell than outside, salt particles will move out of the cell. Diffusion is a type of passive transport, a movement of particles that does not require energy to occur. Facilitated diffusion is a kind of passive transport where proteins in the cell membrane help particles move from high to low concentration.

The cell membrane functions most like a?

Answers

Answer:The cell membrane controls the movement of substances in and out of cells and organelles. In this way, it is selectively permeable to ions and organic molecules.

Explanation:

Which is an example of cooperation?
A. Individual ants together make up an ants’ nest
B. When an organism finds a new way to get itself water
C. When an organism is more successful at hunting than another
D. When people get together to stop the killing of the hawks, skunks, and weasels
Can somebody explain me, between option A and D... why option D is the right answer?(*)
(*) because someone else asked this question and people chose D here in Brainly, but there was not an explanation.
Thank you!

Answers

A is just stating that they make up the nest, D is them actively working together to stop it. A is just a community

Answer:

D. When people get together to stop the killing of the hawks, skunks, and weasels.

Explanation:

A and D make answering this problem a bit confusing, but it's the wording that matters.

Answer A, states that Individual ants together make up an ants' nest. In other words, 1 + 1 + 1 + 1 + 1 + 1 + 1 = 7  

Great, we understand that a bunch of ants means there's an ants nest in that area, but on the other hand...

Answer D, states that people get together to stop the killing of hawks, skunks, and weasels. Which means, people get together WITH A PURPOSE to stop the killing... And in order to have a purpose to stop the killing, the people must cooperate to make a change.

Otherwise, a crowd of people is just a crowd. No purpose, and no reason  for cooperation like the answer choice in A with ants.

You got this! Good Luck! <3

What is black soil best for?
O constructing buildings
O having a wildlife environment
O having a desert environment
O farming land

Answers

Answer:

I believe the answer is farming

Answer:

having a wildlife environment

Explanation:

I took the test and this was the correct answer so your welcome

HELP!! 30 POINTS
BIOLOGY HELPPPPPPPPPPPPPPPPPPPP

HELP!! 30 POINTSBIOLOGY HELPPPPPPPPPPPPPPPPPPPP

Answers

1. Process one is aerobic and the process is called Aerobic Respiration
2. Process two is anaerobic and the process is called Anaerobic Respiration.
3. Aerobic respiration produces more ATP

Which of the following should be used to make a precise measurement of
liquid volume?
A. Microscope
B. Test tube
C. Thermometer
D. Graduated cylinder

Answers

Answer and Explanation:

D. Graduated Cylinder

You use a Graduated Cylinder. Graduated cylinders have numbers on the side that help you determine the volume. Volume is measured in units called liters or fractions of liters called milliliters (ml).

The Graduated Cylinder used to make a precise measure of liquid volume. Graduated cylinders have digits on the side that help you select the volume. Volume is measured in units called liters or fractions of liters called milliliters (ml).

What tool is used to measure the volume of a solid?

A volume of water adequate to cover the things is placed in a graduated cylinder and the volume read.

The entity is added to the cylinder and the volume read again. The contrast between the two volumes is the volume of the object.

Thus,The Graduated Cylinder used to make a precise measure of liquid volume.

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What are the characteristics of carbohydrates? (select all the apply)



(A) contains phosphorus


(B) building material


(C) moves on its own


(D) source of energy

Answers

the characteristics would be options D and B

Carbohydrates are the nutrients that are most frequently employed as an energy source. Monosaccharides are single sugar molecules that serve as the building  for all other sugars and carbohydrates. Thus option B and D are correct.

What is carbohydrates?

Sugar molecules make up carbohydrates, or carbs. Carbohydrates are one of the three primary nutrients included in foods and beverages, along with proteins and fats.

Glucose is created by your body's breakdown of carbs. The primary source of energy for the cells, tissues, and organs in your body is glucose, sometimes known as blood sugar.

A vast variety of both good and bad foods, including bread, beans, milk, popcorn, potatoes, cookies, spaghetti, soft drinks, corn, and cherry pie, include carbohydrates.

They can take on various shapes as well. Starches, fibers, and sugars are the most common and ubiquitous types.

Therefore, carbohydrates serve as source of energy and building material.

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.Why do you think some animals migrate while others are able to live in the same place year round? ​

Answers

Answer:

Climate and Weather: Some animals migrate to avoid extreme weather conditions, such as cold winters or dry seasons. By moving to more favorable climates, they can find suitable temperatures, avoid resource scarcity, or escape harsh environmental conditions.

Answer:

There are several reasons why some animals migrate while others are able to live in the same place year-round. One of the main reasons is related to the availability of resources such as food, water, and shelter. Animals that live in areas with a stable and predictable supply of resources may not need to migrate, while those that live in areas with seasonal changes in resource availability may need to move to find food and water.

Another factor that can influence migration is climate. Animals that are adapted to cold temperatures may migrate to warmer areas during the winter months, while those that are adapted to warmer temperatures may migrate to cooler areas during the summer months.

Genetics and evolution can also play a role in migration patterns. Some species have evolved to migrate as a way to avoid predators or to take advantage of seasonal changes in resource availability. Other species have evolved to stay in one place year-round and have developed adaptations that allow them to survive in their environment without the need to migrate.

Overall, the decision to migrate or stay in one place year-round is influenced by a complex interplay of environmental, genetic, and evolutionary factors.

Edrei went to the doctor for her annual checkup. The
doctor gave her a full physical exam. Then she compared
all data with the previous year's results and said,
"Congratulations on a successful year of mitosis!'
Which statement best explains the doctor's comment?
A. Edrei no longer needs to wear glasses.
B. Edrei has started jogging regularly.
C. Edrei has grown taller.
D. Edrei's allergies have improved.

Answers

I think the answer is A

Plz help me I am timed well mark brainliest if you are correct!

Plz help me I am timed well mark brainliest if you are correct!

Answers

Answer:

The answer is A

Explanation:

Answer:

A) elliptical path

Explanation:

have a nice day!! :)

Knowing that CO2 is a critical greenhouse gas that controls temperature over long timescales, how would a long period of excessive volcanism affect the Earth’s temperature?

Answers

High levels of carbon dioxide would cause the temperature to rise

what is the difference between cork formation and gum formation in the plants as an immune mechanism​

Answers

Answer:

Cork formation is a type of secondary growth that occurs in the stems and roots of woody plants. Gum formation, on the other hand, is a type of defense mechanism that occurs in response to injury or infection.

Explanation:

Osteoporosis is more prevalent among women than men because women generally
have more bones in their bodies than men have.
take in more calcium than men take in.
have lower bone mass than men have.
exercise more than men do

Answers

Answer:

Have lower bone mass than men have

Explanation:

Osteoporosis is a bone thinning disease that is more prevalent among women than men and typically occurs after 50. The reason women are more likely to get the disease than men is because after 50 many women have gone through or are going through menopause. Menopause causes the ovaries to produce less estrogen which is what had previously been promoting bone density.

The other answers are incorrect because...

A: have more bones in their bodies than men have: for the most part everyone has the same amount of bone in there body (although there are diseases that cause a persons bones to fuse together making them have fewer bones than the average person)

B: take in more calcium then men take in: more calcium would actually cause someone to be less likely to get osteoporosis because it strengthens the bones.

C: exercise more than men do: Osteoporosis is more common in malnourished women and women who do not get regular physical activity to strengthens there bones. So getting more exercise would actually lessen the chance of getting osteoporosis.

Hope this helps! :)

Put the steps of our solar system's formation in the order scientists think they happened. 1₁ A cloud of gases and dust collapsed and formed a swirling disk as gravity pulled the matter together. Gravity pulled most of the mass in the disk of gas and dust to the center as the Sun formed. ++ Planets formed regular orbits around the Sun because of gravity and inertia, Planets formed as materials in the swirling disk stuck together and were held together by gravity.​

Put the steps of our solar system's formation in the order scientists think they happened. 1 A cloud

Answers

solar system formed about 4.5 billion years ago from a dense cloud of interstellar gas and dust.

How was solar system's formed step by step?The Sun and the planets formed together, 4.6 billion years ago.from a cloud of gas and dust called the solar nebula.A shock wave from a nearby supernova explosion probably initiated the collapse of the solar nebula.The Sun formed in the center, and the planets formed in a thin disk orbiting around it.The planets, in order of their distance outward from the Sun, are Mercury, Venus, Earth, Mars, Jupiter, Saturn, Uranus, and Neptune. Four planets—Jupiter through Neptune—have ring systems, and all but Mercury and Venus have one or more moons.Our solar system formed about 4.5 billion years ago from a dense cloud of interstellar gas and dust. The cloud collapsed, possibly due to the shockwave of a nearby exploding star, called a supernova. When this dust cloud collapsed, it formed a solar nebula—a spinning, swirling disk of material.

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Which type of energy is created by splitting atoms?
A. Fusion
B. Geothermal
C. Fission
D. Tidal

Answers

Atomic fission is the process through which energy is produced. The right answer is C.

Atomic splitting produces a particular form of energy known as fission. It is a nuclear process in which a huge quantity of energy is released along with the splitting of an atom's nucleus into two or more smaller nuclei.

In fission, neutrons are used to hit heavy atomic nuclei, such as uranium-235 or plutonium-239, creating an unstable nucleus.

Then, this nucleus splits into two or more smaller nuclei, releasing more neutrons and a substantial amount of energy in the process.

Thus, the correct option is C.

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How can cells store the sugar that is produced in photosynthesis?

Answers

Answer:

it is stored as starch

Explanation:

Answer: It is stored as starch.

Explanation: that's what I would say. hope this helps and I hope you have a super fantastic day:)

the rate of cell division(how often cells divide)?
A is the same for all cells
B is different depending on the type of cell and /or the conditions the cells is in.
C is different depending on the type of cell
D is the same for most cells except for sperm and egg cells.​

Answers

Answer:

i dont know

Explanation:

BRAINLIEST
CAN SOMEONE PLZ HELP ME!!

BRAINLIEST CAN SOMEONE PLZ HELP ME!!

Answers

Explanation:

I’m pretty sure it’s phenotypes

PLS ANSWER I WILL GIVE BRAINLIEST

write a short paragraph (5 sentences or more) about photosynthesis using (all) the terms plant, chloroplast, chlorophyll, pigment, sugar, oxygen, and sunlight.

PLS ANSWER I WILL GIVE BRAINLIEST write a short paragraph (5 sentences or more) about photosynthesis

Answers

Answer:

Photosynthesis is a process used by plants and other organisms to convert light energy into chemical energy that can later be released to fuel the organisms' activities. This chemical energy is stored in carbohydrate molecules, such as sugars, which are synthesized from carbon dioxide and water, "light", and sunthesis, "putting together". In most cases, oxygen is also released as a waste product. Most plants, most algae, and cyanobacteria perform photosynthesis; such organisms are called photoautotrophs. Photosynthesis is largely responsible for producing and maintaining the oxygen content of the Earth's atmosphere, and supplies most of the energy necessary for life on Earth.

Although photosynthesis is performed differently by different species, the process always begins when energy from light is absorbed by proteins called reaction centres that contain green chlorophyll pigments. In plants, these proteins are held inside organelles called chloroplasts, which are most abundant in leaf cells, while in bacteria they are embedded in the plasma membrane. In these light-dependent reactions, some energy is used to strip electrons from suitable substances, such as water, producing oxygen gas. The hydrogen freed by the splitting of water is used in the creation of two further compounds that serve as short-term stores of energy, enabling its transfer to drive other reactions: these compounds are reduced nicotinamide adenine dinucleotide phosphate (NADPH) and adenosine triphosphate (ATP).

The chloroplast is the site of photosynthesis. Part of the photosynthesis reactions occurs in an internal membrane within the organelle.

Photosynthesis is the process by which green plants and certain other organisms transform light energy into chemical energy. During photosynthesis in green plants, Sunlight energy is captured and used to convert water, carbon dioxide, and minerals into oxygen and energy-rich organic compounds{sugars)

Chlorophyll is a green coloured pigment present in the leaves of plants. Chlorophyll absorbs the solar energy from the sunlight during the process of photosynthesis.

What are the 3 stages of photosynthesis?

The three steps that occur during the process of photosynthesis are:

(i) Absorption of light energy by chlorophyll.

(ii) Conversion of light energy to chemical energy and splitting of water molecules into hydrogen and oxygen.

(iii) Reduction of carbon dioxide to carbohydrates.

Thus, photosynthesis is an energy driving process in plants.

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What is a community?
A. The smallest part of an element or compound
B. The smallest level at which life exists
C. Several populations of organisms living together
D. A group of one kind of organism living in an area

Answers

Answer:

the answer is c. a community interacts with each other

this segment best represent ls the products of the reaction…abcdor e

this segment best represent ls the products of the reactionabcdor e

Answers

This picture is all about enzyme catabolism.

The answer is B.

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